Familial cancer of the colon and rectum.

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Familial cancer of the colon and rectum.

A familial relationship between intestinal polyposis and the predisposition of polyposis to colonic cancer has been accepted since the publication in 1952/1953 of Dukes's paper. He collected information on every patient presenting at St Mark's Hospital with polyposis coli and investigated the family background in each case. He was able to study 41 families, trace 156 cases of polyposis, and 114...

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comparison of colon and rectum cancer: survival and prognostic factors

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Hereditary and familial colon cancer.

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to ...

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ژورنال

عنوان ژورنال: Journal of Medical Genetics

سال: 1972

ISSN: 1468-6244

DOI: 10.1136/jmg.9.4.451